serglycin

serglycin
An intracellular proteoglycan, found particularly in the storage granules of connective tissue mast cells. The core protein consists of 153 amino acids with 24 serine-glycine repeats between amino acids 89 and 137, hence the name. The serine-glycine repeats are the linkage sites for around 15 glycosaminoglycan chains that are either heparin or highly sulphated chondroitin sulphate. These negatively charged chains are thought to concentrate positively charged proteases, histamine and other molecules within the storage granules.

Dictionary of molecular biology. 2004.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • serglycin — ser·gly·cin (ser gliґsin) an intracellular proteoglycan, consisting of a 12 kD core with 24 serine glycine repeats that are the attachment sites for about 15 glycosaminoglycans; it is expressed by leukocytes and binds histamine in secretory… …   Medical dictionary

  • SRGN — Serglycin, also known as SRGN, is a human gene.cite web | title = Entrez Gene: SRGN serglycin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5552| accessdate = ] PBB Summary section title = summary text =… …   Wikipedia

  • Platelet factor 4 — (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C X C motif) ligand 4 (CXCL4) . This chemokine is released from alpha granules of activated platelets during platelet aggregation, and promotes blood …   Wikipedia

  • Degranulation — The degranulation process in a Mast cell. 1 = antigen; 2 = IgE; 3 = FcεRI; 4 = preformed mediators (histamine, proteases, chemokines, heparin); 5 = granules; 6 Mast cell; 7 newly formed mediators (prostaglandins, leukotrienes, t …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”